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TISSUE REPLICATION

Perfecta3D™ Cell Culture Scaffolds are an organized 3D environment for culturing and testing cells in a reproducible manner, specifically designed for pharmaceutical testing, with applications in cell expansion, tissue engineering, and cell imaging.

Bone Marrow and Blood

Notch ligand presenting acellular 3D microenvironments for ex vivo human hematopoietic stem-cell culture made by layer-by-layer assembly. Lee J, Kotov NA. Small.2009 May; 5(9):1008-13.

In vitro analog of human bone marrow from 3D scaffolds with biomimetic inverted colloidal crystal geometry. Nichols JE, Cortiella J, Lee J, Niles JA, Cuddihy M, Wang S, Bielitzki J, Cantu A, Mlcak R, Valdivia E, Yancy R, McClure ML, Kotov NA. Biomaterials. 2009 Feb; 30(6): 1071-9.

Prolonged continuous in vitro human platelet production using three-dimensional scaffolds. Sullenbarger B, Bahng JH, Gruner R, Kotov N, Lasky LC. Experimental Hematology. 2009 Jan; 37(1):101-10.

Inverted colloidal crystals as three-dimensional microenvironments for cellular co-cultures. Lee J, Shanbhag S, Kotov NA. J. Mater. Chem. 2006; 16:3558-64.

Bone

Poly(lactic-co-glycolic acid) bone scaffolds with inverted colloidal crystal geometry. Cuddihy MJ, Kotov NA. Tissue Eng Part A. 2008 Oct; 14(10):1639-49.

Liver

Engineering liver tissue spheroids with inverted colloidal crystal scaffolds. Lee J, Cuddihy MJ, Cater GM, Kotov NA. Biomaterials. 2009 Sep; 30(27):4687-94.

In vitro toxicity testing of nanoparticle in 3D cell culture. Lee J, Lilly GD, Doty RC, Podsiadlo P, Kotov NA. Small. 2009 May; 5(10):1213-21.

Skin

In vitro integration of human skin dermis with porous cationic hydrogels. Peramo A, Bahng JH, Marcelo CL, Kotov N, Martin DC. Acta Biomater. 2009 Nov; 5 (9): 3337-45.