3D Biomatrix In The News

Xconomy Detroit – 3D Biomatrix Hopes To Break Into Drug Discovery Market With 3D Testing Devices (7/7/11) 3D Biomatrix is developing ways for drug researchers to test their therapies on cells with three dimensions. Scientists can better screen drug candidates on cells that offer a more realistic human response to potential therapies, CEO Laura Schrader says.

3D Biomatrix’s Perfecta3D™ Hanging Drop Plates wins poster award at LabAutomation 2011 (February 2011) Three-dimensional (3D) culture of cells is motivated by the need to work with accurate in vitro models that closely mimic physiological tissues. A new 3D cell culture plate technology is based on the scientifically proven but traditionally tedious hanging drop method to form 3D spheroids from multiple cell types. This novel hanging drop array platform allows for efficient formation of uniformly-sized spheroids, their long-term culture, and drug testing using liquid handling robots and plate readers. Read poster

3D Biomatrix’s Perfecta3D™ Hanging Drop Plates featured on the front cover of Analyst (February 2011) Culture of cells as three-dimensional (3D) aggregates can enhance in vitro tests for basic biological research as well as for therapeutics development. A novel 384-well format hanging drop culture plate makes spheroid formation, culture, and subsequent drug testing straightforward to perform and adapt to existing high-throughput screening (HTS) instruments. The 3D hanging drop culture and testing plate provides an efficient way to obtain biological insights that are often lost in 2D platforms. Read paper

Toxicology: Testing in the third dimension: Nature Nanotechnology (June 2009) Experiments with a new three-dimensional model of liver tissue find that the toxic effects of nanoparticles are reduced when compared with tests that use two-dimensional models. Read paper

3D nanotoxicity tests more accurate than 2D, says study: Cosmetics-Design, Europe (April 1, 2009) Using 3D tissue models may be more accurate than 2D when testing the toxicity of nanoparticles, say scientists in the US. A scaffold material that supports the growth of cells within a three dimensional environment can be used to develop in-vitrotests that better mimic the behavior of human cells, according to the research published in Small.

Bone in a bottle: The Economist (Mar 5th 2009) Attempts to grow artificial bone marrow in the laboratory have failed—but now a new approach is showing promise.

Artificial bone marrow in test tube produces red and white blood cells: Nanowerk News, (Dec 2008) Artificial bone marrow that can continuously make red and white blood cells has been created in a University of Michigan lab. This development could lead to simpler pharmaceutical drug testing, closer study of immune system defects and a continuous supply of blood for transfusions.

Artificial bone marrow created, can grow blood keeping supplies high: TechGeneration Daily (Dec 2008) Imagine blood banks that are constantly stocked even when donors are low. Or the ability to reproduce your own blood, your own antibodies directly and continuously even if your bone marrow is damaged by some form of drug treatment, just by taking a sample before the medications are given. We at TG Daily don’t believe the significance of this finding can be overstated. This is the kind of research that earns people Nobel Prizes.

Artificial Human Bone Marrow Created In A Test Tube: Science Daily (Dec. 23, 2008) Artificial bone marrow that can continuously make red and white blood cells has been created in a University of Michigan lab.

New way to learn drug side effects? The Ann Arbor News (Aug, 2008)