Category Archives: 3D Biomatrix Blog Page

Perfecta3D® Hanging Drop Plates gain awareness according to HTStec’s 2011 3D Cell Culture Report HTStec conducted its second industry-wide global web-based benchmarking survey on three-dimensional (3D) cell culture (http://www.htstec.com/consultancyitem.aspx?Item=332). The study aimed to document current interest and progress made in applying 3D cell culture techniques in academic research, drug discovery and tissue engineering/regenerative medicine settings, Continue Reading

The recent article on contaminated and misidentified cell lines in the Wall Street Journal gave a sobering mainstream look at a problem that has been discussed (and maybe ignored) in the cell culture research community for years. This is obviously a serious problem that needs to be overcome with better procedures, record keeping, and housekeeping. Continue Reading

AstraZeneca, Eli Lilly & Co, and Pfizer announced recently that they were going to open up their freezers and allow for some of their shelved drugs to be tested through an NIH program. These are drugs that were proven to be safe in human trials, but failed to treat the disease that the drugmaker had Continue Reading

Recently we noticed an interesting post on “In the Pipeline,” an informative drug discovery blog by Derek Lowe. In his post, he summarizes a response from John LaMattina at Forbes to a speech by Dr. Janet Woodcock, Director of the Center for Drug Evaluation and Research at the FDA about drug failures. Lowe mentions, “Of Continue Reading

We hate to brag, but the AACR Annual meeting Exhibit Show was a big hit this year. 3D Biomatrix was impressed at how many cancer researchers were either interested or were already using 3D cell cultures. The attendees really understood the relevance of 3D cell cultures to cancer research and testing. And, they really liked Continue Reading

Co-culture spheroids as new preclinical models for understanding tumor initiation and progression and developing therapies Get ready for the next-generation of preclinical in vitro tumor models! Researchers have recently shown that co-cultures of tumor and stromal cells assembled into three-dimensional (3D) spheroids can provide better understanding of cancer therapeutics and facilitate establishment of improved pharmacokinetics, Continue Reading

Multi-cell type spheroids recapitulate complex microenvironments So, you are considering 3D spheroid culture as an alternative or complement to the reductionist in vitro models offered by 2D monolayer cell culture. How can you exploit 3D spheroid culture to develop a powerful experimental tool to answer your research questions? The ability to recreate the complex microenvironments Continue Reading

Earlier this month, the Cambridge Health Institute held its Sixth Annual Human Predictive Functional Tissue Models Conference in Boston, MA. A theme of the conference was “Moving into the Third Dimension,” and talks within this theme focused on the relevance and potential impact of three-dimensional (3D) cell cultures. In the opening talk, given by James Continue Reading

Wondering if your cells will form spheroids in our Perfecta3DTM Hanging Drop Plates? Chances are they will. Together with our collaborators, we’ve been able to show that more than 20 cell lines form spheroids in our Hanging Drop Plates. The formation of spheroids from cell lines from several mammals (human, mouse, monkey) demonstrates that the Continue Reading

The inventor of 3D Biomatrix’s Perfecta3DTM Hanging Drop Plates was recently featured in the influential biotechnology industry publication Genetic Engineering & Biotechnology News. The University of Michigan Professor of Biomedical Engineering and Macromolecular Sciences Shuichi Takayama was highlighted in a recent article on three dimensional (3D) cell culture after a recent presentation he gave at Continue Reading